PATERNAL AGE AFFECTS OFFSPRING'S BEHAVIOR POSSIBLY VIA EPIGENETIC MECHANISM RECRUITING A TRANSCRIPTIONAL REPRESSOR REST
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چکیده
منابع مشابه
REST is a hypoxia-responsive transcriptional repressor
Cellular exposure to hypoxia results in altered gene expression in a range of physiologic and pathophysiologic states. Discrete cohorts of genes can be either up- or down-regulated in response to hypoxia. While the Hypoxia-Inducible Factor (HIF) is the primary driver of hypoxia-induced adaptive gene expression, less is known about the signalling mechanisms regulating hypoxia-dependent gene repr...
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Neurogenesis begins in embryonic development and continues at a reduced rate into adulthood in vertebrate species, yet the signaling cascades regulating this process remain poorly understood. Plasma membrane-initiated signaling cascades regulate neurogenesis via downstream pathways including components of the transcriptional machinery. A nuclear factor that temporally regulates neurogenesis by ...
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Neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit and hyperactivity disorder (ADHD) have increased over the last few decades. These neurodevelopmental disorders are characterized by a complex etiology, which involves multiple genes and gene-environmental interactions. Various genes that control specific properties of neural development exert pivotal roles...
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ژورنال
عنوان ژورنال: European Neuropsychopharmacology
سال: 2019
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2017.08.089